Biomedicines, Free Full-Text
Por um escritor misterioso
Descrição
Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated in the pathogenesis of various brain diseases, including neurodegenerative disorders, stroke, and psychiatric illnesses. This review paper provides a comprehensive overview of the intricate relationship between mitochondria and brain disease, focusing on the underlying pathological mechanisms and exploring potential therapeutic opportunities. The review covers key topics such as mitochondrial DNA mutations, impaired oxidative phosphorylation, mitochondrial dynamics, calcium dysregulation, and reactive oxygen species generation in the context of brain disease. Additionally, it discusses emerging strategies targeting mitochondrial dysfunction, including mitochondrial protective agents, metabolic modulators, and gene therapy approaches. By critically analysing the existing literature and recent advancements, this review aims to enhance our understanding of the multifaceted role of mitochondria in brain disease and shed light on novel therapeutic interventions.
![Biomedicines, Free Full-Text](https://www.mdpi.com/biomedicines/biomedicines-11-01801/article_deploy/html/images/biomedicines-11-01801-g001-550.jpg)
Cort De Bono Get File - Colaboratory
![Biomedicines, Free Full-Text](https://www.bjbms.org/images/BJBMS_Statistics_2022.png)
Biomolecules and Biomedicine
![Biomedicines, Free Full-Text](https://pub.mdpi-res.com/biomedicines/biomedicines-12-00003/article_deploy/html/images/biomedicines-12-00003-g006-550.jpg?1702970827)
Biomedicines An Open Access Journal from MDPI
![Biomedicines, Free Full-Text](https://ars.els-cdn.com/content/image/1-s2.0-S1532046422000983-ga1.jpg)
Topological data analysis in biomedicine: A review - ScienceDirect
![Biomedicines, Free Full-Text](https://pub.mdpi-res.com/biomedicines/biomedicines-11-03342/article_deploy/html/images/biomedicines-11-03342-g003-550.jpg?1702891115)
Biomedicines An Open Access Journal from MDPI
![Biomedicines, Free Full-Text](https://www.science.org/cms/asset/59b825e5-2ab0-4497-b407-2086336b6968/aay6125-f1.gif)
Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles
![Biomedicines, Free Full-Text](https://i0.wp.com/inergency.com/wp-content/uploads/2023/12/biomedicines-11-03335-g001-550.jpg?resize=450%2C224&ssl=1)
Biomedicines, Free Full-Text
![Biomedicines, Free Full-Text](https://www.thelancet.com/cms/asset/ed62d6fc-6c30-44b8-b3c5-b947612e066e/gr1.jpg)
Maternal exposure to ambient black carbon particles and their presence in maternal and fetal circulation and organs: an analysis of two independent population-based observational studies - The Lancet Planetary Health
![Biomedicines, Free Full-Text](https://www.completeomics.com/wp-content/uploads/2021/11/generate-biomedicines.jpg)
Collaboration with Generate Biomedicines
![Biomedicines, Free Full-Text](https://www.cell.com/cms/asset/7ae0080c-5afb-4027-9546-9442c981cfd2/fx1.jpg)
Nonclinical pharmacokinetics and biodistribution of VSV-GP using methods to decouple input drug disposition and viral replication: Molecular Therapy - Methods & Clinical Development
de
por adulto (o preço varia de acordo com o tamanho do grupo)