JoF, Free Full-Text
Por um escritor misterioso
Descrição
Paracoccidioidomycosis (PCM) is a systemic mycosis caused by fungi of the genus Paracoccidioides and the different clinical forms of the disease are associated with the host immune responses. Quantitative trait loci mapping analysis was performed to assess genetic variants associated with mononuclear-cells-derived cytokines induced by P. brasiliensis on 158 individuals. We identified the rs11053595 SNP, which is present in the CLEC7A gene (encodes the Dectin-1 receptor) and the rs62290169 SNP located in the PROM1 gene (encodes CD133) associated with the production of IL-1β and IL-22, respectively. Functionally, the blockade of the dectin-1 receptor abolished the IL-1β production in P. brasiliensis-stimulated PBMCs. Moreover, the rs62290169-GG genotype was associated with higher frequency of CD38+ Th1 cells in PBMCs cultured with P. brasiliensis yeasts. Therefore, our research indicates that the CLEC7A and PROM1 genes are important for the cytokine response induced by P. brasiliensis and may influence the Paracoccidioidomycosis disease outcome.
![JoF, Free Full-Text](https://ivypanda.com/blog/wp-content/uploads/2020/11/directory-of-open-access-books-768x247-1.png)
Term Papers Online: 90+ FREE Websites for Your Paper
![JoF, Free Full-Text](https://pub.mdpi-res.com/jof/jof-09-01204/article_deploy/html/images/jof-09-01204-g004-550.jpg?1702715994)
Journal of Fungi An Open Access Journal from MDPI
![JoF, Free Full-Text](https://www.mdpi.com/ijms/ijms-16-26147/article_deploy/html/images/ijms-16-26147-g001-1024.png)
IJMS, Free Full-Text
3 Smart Ways to Download Free Full Text Articles for Your Literature Review
![JoF, Free Full-Text](https://onlinelibrary.wiley.com/pb-assets/assets/10969071/jmv.v92.6.cover-1587515150853.jpg)
Journal of Medical Virology - Wiley Online Library
![JoF, Free Full-Text](https://pic.onlinewebfonts.com/screenshots/439a001f17a6c04bfba14f4bebc4b0ee.jpg)
Joufflou NF W01 Regular 1.10 Fonts Free Download
![JoF, Free Full-Text](https://media.fontsgeek.com/generated/j/o/jot-regular-sample.png)
Jot Regular : Download For Free, View Sample Text, Rating And More On
![JoF, Free Full-Text](https://justanotherfoundry.com/img/twitter-cards/2014-08-JAF_Johannes_bw.png)
Just Another Foundry – JAF Johannes
![JoF, Free Full-Text](https://i0.wp.com/www.dafontfree.co/wp-content/uploads/2021/09/big-john-slim-joe-font.png?resize=1000%2C800)
Big John / Slim Joe Font - Dafont Free
de
por adulto (o preço varia de acordo com o tamanho do grupo)